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Here is the exact definition:
To express extreme exasperation, shock, or dismay. A magnification of fuck me. Metaphoric exaggeration of being fucked while trying to run.
No clue- my guess would be they think you've lost your mind and don't want to be anywhere around nor associated with you in the future
It's almost like, Holy Shit, or Damn it...I say fuck me runnin' backwards. With the unbelievable crap I see and put up with, it's likely you'll hear that from me... a lot.
“Sometimes the questions are complicated and the answers are simple.”
― Dr. Seuss